I'd really like to help, but you need o provide details.
VMware offers tons of products on which you can install VMs (e.g. Workstation, Player, Fusion,. ESXi), and the VMs can be any operating system.
So please clarify which product you are using, which operating system you've installed in the VM (make/version), and which application (vendor/version) you are trying to run. Also let us know which issues you have, and if there are any error messages.
André